Publications

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Designing HIV Testing Algorithms Based on 2015 WHO Guidelines Using Data from Six Sites in Sub-Saharan Africa.

Abstract

Our objective was to evaluate the performance of HIV testing algorithms based on WHO recommendations, using data from specimens collected at six HIV testing and counseling sites in sub-Saharan Africa (Conakry, Guinea; Kitgum and Arua, Uganda; Homa Bay,

Kosack CS Shanks L Beelaert G Benson T Savane A Ng'ang'a A Bita A Zahinda JBN Fransen K Page AL
Journal of clinical microbiology 2017 10 ; 55(10); 3006-3015. doi: 10.1128/JCM.00962-17. Epub 2017 07 26
WHO guidelines diagnostic accuracy diagnostic algorithms human immunodeficiency virus positive predictive value rapid tests

A comparison of self-report and antiretroviral detection to inform estimates of antiretroviral therapy coverage, viral load suppression and HIV incidence in Kwazulu-Natal, South Africa.

Abstract

BACKGROUND: Accurately identifying individuals who are on antiretroviral therapy (ART) is important to determine ART coverage and proportion on ART who are virally suppressed.

Huerga H Shiferie F Grebe E Giuliani R Farhat JB Van-Cutsem G Cohen K
BMC infectious diseases 2017 09 29; 17(1); 653. doi: 10.1186/s12879-017-2740-y. Epub 2017 09 29
ART ARV detection Antiretroviral coverage HIV HIV incidence Self-report Viral suppression

Carriage prevalence and serotype distribution of Streptococcus pneumoniae prior to 10-valent pneumococcal vaccine introduction: A population-based cross-sectional study in South Western Uganda, 2014.

Abstract

BACKGROUND: Information on Streptococcus pneumoniae nasopharyngeal (NP) carriage before the pneumococcal conjugate vaccine (PCV) introduction is essential to monitor impact.

Nackers F Cohuet S le Polain de Waroux O Langendorf C Nyehangane D Ndazima D Nanjebe D Karani A Tumwesigye E Mwanga-Amumpaire J Scott JAG Grais RF
Vaccine 2017 09 18; 35(39); 5271-5277. doi: 10.1016/j.vaccine.2017.07.081. Epub 2017 08 04
Adult Children Nasopharyngeal carriage Pneumococcal conjugate vaccine Pneumococcal serotypes Streptococcus pneumoniae Uganda

Prevalence of antibodies to Brucella species in commercial raw bovine milk in Southwestern Uganda.

Abstract

OBJECTIVES: The purpose and objective of this research was to explore the prevalence of antibodies against Brucella species in raw milk samples collected in Southwestern Uganda, one of the biggest milk producing regions in the Country.

Kamwine M Orikiriza P Taseera K Iramiot JS Ojuka P Ikiriza S Atwebembeire J Otieno D Tweshengyereze S Mwanga-Amumpaire J Bazira J Boum Y
BMC research notes 2017 Sep 08; 10(1); 215. doi: 10.1186/s13104-017-2537-5. Epub 2017 09 08
Brucellosis Diagnosis Indirect ELISA Milk ring test

A guide to aid the selection of diagnostic tests.

Abstract

In recent years, a wide range of diagnostic tests has become available for use in resource-constrained settings. Accordingly, a huge number of guidelines, performance evaluations and implementation reports have been produced.

Kosack CS Page AL Klatser PR
Bulletin of the World Health Organization 2017 Sep 01; 95(9); 639-645. doi: 10.2471/BLT.16.187468. Epub 2017 06 26

Adherence, tolerability, and outcome after 36 months of isoniazid-preventive therapy in 2 rural clinics of Swaziland: A prospective observational feasibility study.

Abstract

Although efficacy of 36 months isoniazid preventive therapy (IPT) among HIV-positive individuals has been proven in trial settings, outcome, tolerance, and adherence have rarely been evaluated in real-life settings.This is a prospective observational c

Mueller Y Mpala Q Kerschberger B Rusch B Mchunu G Mazibuko S Bonnet M
Medicine 2017 Sep ; 96(35); e7740. doi: 10.1097/MD.0000000000007740. Epub 2017 09 11

Prospective cohort study of the feasibility and yield of household child tuberculosis contact screening in Uganda.

Abstract

SETTING: Screening and isoniazid preventive therapy (IPT) of child contacts of tuberculosis (TB) patients is poorly implemented in resource-limited countries, in part due to difficulties in TB diagnosis in children.

Bonnet M Kyakwera C Kyomugasho N Atwine D Mugabe F Nansumba M Ii YB Mwanga-Amumpaire J Kiwanuka J
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2017 08 01; 21(8); 862-868. doi: 10.5588/ijtld.16.0889. Epub 2018 04 26

Combined interventions to reduce HIV incidence in KwaZulu-Natal: a modelling study.

Abstract

BACKGROUND: Combined prevention interventions, including early antiretroviral therapy initiation, may substantially reduce HIV incidence in hyperendemic settings.

Blaizot S Huerga H Riche B Ellman T Shroufi A Etard JF Ecochard R
BMC infectious diseases 2017 07 26; 17(1); 522. doi: 10.1186/s12879-017-2612-5. Epub 2017 07 26
Antiretroviral therapy HIV Male circumcision Mathematical models Pre-exposure prophylaxis South Africa
Isanaka S Djibo A Grais RF
The New England journal of medicine 2017 07 20; 377(3); 302. doi: 10.1056/NEJMc1705793. Epub 2017 07 24

HIV misdiagnosis in sub-Saharan Africa: performance of diagnostic algorithms at six testing sites.

Abstract

INTRODUCTION: We evaluated the diagnostic accuracy of HIV testing algorithms at six programmes in five sub-Saharan African countries.

Kosack CS Shanks L Beelaert G Benson T Savane A Ng'ang'a A Andre B Zahinda JB Fransen K Page AL
Journal of the International AIDS Society 2017 07 03; 20(1); 21419. doi: 10.7448/IAS.20.1.21419. Epub 2017 11 16
HIV RDT algorithm diagnostic misdiagnosis test