Publications

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Impact of systematic early tuberculosis detection using Xpert MTB/RIF Ultra in children with severe pneumonia in high tuberculosis burden countries (TB-Speed pneumonia): a stepped wedge cluster randomized trial.

Abstract

BACKGROUND: In high tuberculosis (TB) burden settings, there is growing evidence that TB is common in children with pneumonia, the leading cause of death in children under 5 years worldwide.

Vessière A Font H Gabillard D Adonis-Koffi L Borand L Chabala C Khosa C Mavale S Moh R Mulenga V Mwanga-Amumpere J Taguebue JV Eang MT Delacourt C Seddon JA Lounnas M Godreuil S Wobudeya E Bonnet M Marcy O
BMC pediatrics 2021 03 20; 21(1); . doi: 10.1186/s12887-021-02576-5. Epub 2021 03 20
Children Nasopharyngeal aspirate Pneumonia Stool Tuberculosis Xpert MTB/RIF ultra

Decentralised hepatitis C testing and treatment in rural Cambodia: evaluation of a simplified service model integrated in an existing public health system.

Abstract

BACKGROUND: Direct-acting antiviral treatment for hepatitis C virus (HCV) has provided the opportunity for simplified models of care delivered in decentralised settings by non-specialist clinical personnel.

Meiwen Zhang Daniel O’Keefe Jennifer Craig Keo Samley Voeurng Bunreth Pascal Jolivet Suna Balkan Tonia Marquardt Jean-Philippe Dousset Mickael Le Paih
Lancet Gastroenterol Hepatol 2021 Published Online March 18, 2021. doi.org/10.1016/S2468-1253(21)00012-1
Hépatite C Evaluation Cambodge

Community intervention for child tuberculosis active contact investigation and management: study protocol for a parallel cluster randomized controlled trial.

Abstract

BACKGROUND: There are major gaps in the management of pediatric tuberculosis (TB) contact investigation for rapid identification of active tuberculosis and initiation of preventive therapy.

Vasiliu A Eymard-Duvernay S Tchounga B Atwine D de Carvalho E Ouedraogo S Kakinda M Tchendjou P Turyahabwe S Kuate AK Tiendrebeogo G Dodd PJ Graham SM Cohn J Casenghi M Bonnet M
Trials 2021 Mar 02; 22(1); 180. doi: 10.1186/s13063-021-05124-9. Epub 2021 03 02
Cluster randomized controlled trial Community intervention Contact tracing Pediatric tuberculosis Preventive therapy Tuberculosis symptom screening

Improving estimates of the burden of severe wasting: analysis of secondary prevalence and incidence data from 352 sites.

Abstract

INTRODUCTION: Estimates of incident cases of severe wasting among young children are not available for most settings but are needed for optimal planning of treatment programmes and burden estimation.

Isanaka S Andersen CT Cousens S Myatt M Briend A Krasevec J Hayashi C Mayberry A Mwirigi L Guerrero S
BMJ global health 2021 03 ; 6(3); doi: 10.1136/bmjgh-2020-004342. Epub 2021 06 24
child health epidemiology nutrition

Hepatitis C viraemic and seroprevalence and risk factors for positivity in Northwest Cambodia: a household cross-sectional serosurvey.

Abstract

BACKGROUND: Despite a dramatic reduction in HCV drug costs and simplified models of care, many countries lack important information on prevalence and risk factors to structure effective HCV services.

Lynch E Falq G Sun C Bunchhoeung PDT Huerga H Loarec A Dousset JP Marquardt T Paih ML Maman D
BMC infectious diseases 2021 Feb 26; 21(1); 223. doi: 10.1186/s12879-021-05826-0. Epub 2021 02 26
Cambodia HCV Hepatitis C MSF Sero-prevalence Serosurvey Viraemia

Surveillance of Plasmodium falciparum pfcrt haplotypes in southwestern uganda by high-resolution melt analysis.

Abstract

BACKGROUND: Chloroquine (CQ) resistance is conferred by mutations in the Plasmodium falciparum CQ resistance transporter (pfcrt).

Kassaza K Long AC McDaniels JM Andre M Fredrickson W Nyehangane D Orikiriza P Operario DJ Bazira J Mwanga-Amumpaire JA Moore CC Guler JL Boum Y
Malaria journal 2021 Feb 25; 20(1); 114. doi: 10.1186/s12936-021-03657-7. Epub 2021 02 25
Chloroquine HRM Plasmodium falciparum Resistance Uganda pfcrt