Publications

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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

  • 2016/12/01
Type de publication
  • Articles
Auteurs
  • Stucki D
  • Brites D
  • Jeljeli L
  • Coscolla M
  • Liu Q
  • Trauner A
  • Fenner L
  • Rutaihwa L
  • Borrell S
  • Luo T
  • Gao Q5
  • Kato-Maeda M
  • Ballif M
  • Egger M
  • Macedo R
  • Mardassi H
  • Moreno M
  • Vilanova GT
  • Fyfe J
  • Globan M
  • Thomas J
  • Jamieson F
  • Guthrie JL
  • Asante-Poku A
  • Yeboah-Manu D
  • Wampande E
  • Ssengooba W
  • Joloba M
  • Boom WH
  • Basu I
  • Bower J
  • Saraiva M
  • Vasconcellos SE
  • Suffys P
  • Koch A
  • Wilkinson R
  • Gail-Bekker L
  • Malla B
  • Ley SD
  • Beck HP
  • de Jong BC
  • Toit K
  • Sanchez-Padilla E
  • Bonnet M
  • Gil-Brusola A
  • Frank M
  • Penlap Beng VN
  • Eisenach K
  • Alani I
  • Ndung'u PW
  • Revathi G
  • Gehre F
  • Akter S
  • Ntoumi F
  • Stewart-Isherwood L
  • Ntinginya NE
  • Rachow A
  • Hoelscher M
  • Cirillo DM
  • Skenders G
  • Hoffner S
  • Bakonyte D
  • Stakenas P
  • Diel R
  • Crudu V
  • Moldovan O
  • Al-Hajoj S
  • Otero L
  • Barletta F
  • Carter EJ
  • Diero L
  • Supply P
  • Comas I
  • Niemann S
  • Gagneux S
Thèmes
  • Tuberculose
Abstract
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration