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High prevalence of multidrug-resistant tuberculosis, Swaziland, 2009-2010

  • 2012/01/02
Type de publication
  • Articles
  • Sanchez-Padilla E
  • Dlamini T
  • Ascorra A
  • Rüsch-Gerdes S
  • Tefera ZD
  • Calain P
  • de la TR
  • Jochims F
  • Richter E
  • Bonnet M;
  • Tuberculose

In Africa, although emergence of multidrug-resistant (MDR) tuberculosis (TB) represents a serious threat in countries severely affected by the HIV epidemic, most countries lack drug-resistant TB data. This finding was particularly true in the Kingdom of Swaziland, which has the world's highest HIV and TB prevalences. Therefore, we conducted a national survey in 2009-2010 to measure prevalence of drug-resistant TB. Of 988 patients screened, 420 new case-patients and 420 previously treated case-patients met the study criteria. Among culture-positive patients, 15.3% new case-patients and 49.5% previously treated case-patients harbored drug-resistant strains. MDR TB prevalence was 7.7% and 33.8% among new case-patients and previously treated case-patients, respectively. HIV infection and past TB treatment were independently associated with MDR TB. The findings assert the need for wide-scale intervention in resource-limited contexts such as Swaziland, where diagnostic and treatment facilities and health personnel are lacking